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. 2024 Jun 4;300(7):107451. doi: 10.1016/j.jbc.2024.107451

Figure 1.

Figure 1

Expressed variants of CR1-containing duplications of LHR domains. All soluble CR1 variants used in this study that containing LHR domain duplications are shown here schematically, with amino acids 42 to 489, 490 to 939, and 940 to 1392 used to define the boundaries of LHR-A, LHR-B, and LHR-C, respectively, based on Met+1. The solid black circle between LHR-A domains in construct LHR-A(GS30)A indicates the location of an in-frame 30 amino acid Gly-Ser linker. CSL040, containing LHR-A, LHR-B, and LHR-C, was used as the primary comparator for all experiments. CR1, complement receptor 1; LHR, long homologous repeat.