Table 3.

Potency of CSL040 fused to CSL040/LHR-ABC in red blood cell hemolytic assays

Human CR1 protein	Hemolytic IC50 (nM) ± SD
	Classical	Alternative
CSL040	0.4 ± 0.1	0.9 ± 0.5
CSL040-HSA	0.3 ± 0.1	0.7 ± 0.3
HSA-CSL040	0.4 ± 0.1	4.5 ± 0.2∗
HSA	No Activity	No Activity

The IC₅₀ values listed are the mean ± SD of three independent experiments, shown graphically in Figure 4. Statistically significant differences for each HSA fusion compared to CSL040 were calculated by an unpaired t test; ∗ p < 0.05.

CR1, complement receptor 1; HSA, human serum albumin; LHR, long homologous repeat.