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In vivo targeted convergence of RNPS. A. Ultrasound imaging of tumor-bearing nude mice at different time points (2, 12, and 24 h) before and after NPs injection. B. Fluorescence imaging of nude mice with tumor after injection of PFH-DOX@PLGA/SPIO-RGD NPs into the tail vein before, 2h, 12h, and 24h postinjection. Arrows showed subcutaneous solid tumors of pancreatic cancer. C.Trend of tumor volume change. D. Trend of weight change of nude mice in each group.
