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CUP-classifier model workflow. The beta values of non-squamous cancer-specific DMCs and squamous cancer-specific DMCs were converted into 68×34 and 30×15 array formats, respectively, and were followed by conversion to IGTD image. The squamous part image was resized to 68×34 and merged with non-squamous part image. Merged images were divided into 17×17 image patches and these patches were used to train the ViT model for classification of CUP.
