Figure 7: Colocalization at rs12610495 confirms the association between the cg07317664-mQTL and DPP9-eQTL signals in IPF cases.

(A) Comparison of −log₁₀(p-values) of cg07317664-mQTLs and DPP9-eQTLs in controls in the Borie et al. datasets shows that rs12610495 in not the lead SNP for either dataset.

(B) Comparison of −log₁₀(p-values) in IPF cases shows rs12610495 as a top shared SNP.

(C) COLOC does not support colocalization between cg07317664-mQTL and DPP9-eQTL signals in controls with PP4 < 0.700 but supports colocalization in IPF cases with PP4 > 0.700.

(D) Box plot for DPP9 expression in lung by diagnosis.

(E) Box plot for normalized methylation beta in lung by diagnosis.