Table 1.

Comparison results for particle picking on EMPIAR-10499 [22].

Method	Annotation Ratio	Precision	Recall	F1 Score	Runtime (min)
EMAN2 [21]	-	26.1	55.3	35.5	2–5
crYOLO [24]	100%	47.8	56.8	52.0	30–40
Huang et al. [8]	5%	49.6	58.1	53.5
	10%	50.1	58.2	53.8
	30%	55.9	60.3	58.0	5–10
	50%	53.0	65.1	58.4
	70%	54.9	66.7	60.2
CryoSAM (Ours)	< 1% (single prompt)	53.1	55.3	54.2
	5%	57.8	74.3	65.0
	10%	58.2	75.1	65.5
	30%	58.1	75.4	65.6	10–15
	50%	58.0	75.3	65.5
	70%	58.5	79.4	67.4