Table 2.

Associations of T2D pPS with baseline and 1-year baseline-adjusted values

Outcome (N = 2,647)	β-Cell pPS		Proinsulin pPS		Obesity pPS		Lipodystrophy pPS		Liver/lipid pPS
	Estimate	P	Estimate	P	Estimate	P	Estimate	P	Estimate	P
BMI, kg/m2
Baseline	−0.6496	1.7 × 10−7	−0.0301	0.814	0.2678	0.032	−0.5483	1.3 × 10−5	0.0061	0.961
1-year adj baseline	0.0519	0.21	−0.0574	0.180	−0.0303	0.470	0.0500	0.230	−0.0204	0.620
Waist, cm
Baseline	−1.2290	1.1 × 10−5	−0.0299	0.918	0.6096	0.030	−1.4584	2.5 × 10−7	0.1025	0.715
1-year adj baseline	0.1025	0.43	0.0076	0.960	−0.0568	0.660	0.2432	0.070	−0.2308	0.080
Triglycerides, mg/dL
Baseline	−2.8280	0.128	0.3748	0.845	0.8656	0.641	4.0744	0.030	−9.3715	3.9 × 10−7
1-year adj baseline	1.5997	0.23	0.1291	0.930	1.6676	0.210	1.5290	0.260	−4.3715	1.0 × 10−3
HbA1c
Baseline, %	−0.0006	0.943	0.0160	0.104	−0.0067	0.491	0.0075	0.430	0.0058	0.530
Baseline, mmol/mol	−23.504		−23.3220		−23.571		−23.4150		−23.434
1-year adj baseline, %	0.0066	0.33	0.0000	0.990	0.0055	0.410	0.0026	0.680	−0.0108	0.100
1-year adj baseline, mmol/mol	−23.425		−23.4970		−23.437		−23.4690		−23.615
Fasting insulin, μU/mL
Baseline	−1.2027	4.6 × 10−5	−0.6455	0.034	−0.4197	0.157	0.4934	0.100	0.2062	0.486
1-year adj baseline	−0.3308	0.23	0.1283	0.670	0.7801	0.010	0.0399	0.890	0.1962	0.490
PIR
Baseline	0.0101	8.9 × 10−5	−0.0045	0.078	−0.0051	0.048	0.0000	0.972	−0.0015	0.587
1-year adj baseline	0.0042	0.14	0.0017	0.560	−0.0029	0.326	0.0013	0.690	−0.0038	0.190
ISI
Baseline	0.0054	0.04	0.0050	0.061	0.0025	0.295	−0.0070	0.007	−0.0019	0.498
1-year adj baseline	0.0048	0.10	−0.0002	0.930	−0.0004	0.850	0.0009	0.800	−0.0035	0.190
IGR (μU/mg)
Baseline	−9.1105	6.4 × 10−7	−2.2354	0.244	−3.1251	0.090	2.9536	0.113	1.5114	0.411
1-year adj baseline	−8.4978	5.6 × 10−6	−2.7241	0.160	0.2252	0.910	−0.0259	0.100	0.1498	0.940
CIR
Baseline	−0.0465	1.5 × 10−8	−0.0155	0.073	−0.0114	0.178	0.0149	0.072	−0.0008	0.913
1-year adj baseline	−0.0417	9.6 × 10−7	−0.0108	0.230	0.0042	0.630	−0.0035	0.700	0.0027	0.760

Estimates are reported per SD. The outcome value at year 1 includes adjustment for the respective trait measurement at baseline (1-year adj baseline).

P values in boldface type indicate significant replication (P < 0.05) for associations with baseline measures and study-wide significant (P < 0.001) for 1 year adjusted for baseline. For baseline, results are reported in natural log transformation scale. For all 1-year baseline-adjusted results, the original scale was used for point estimates (no log transformation).