Table 3. Changes in hemodynamic, blood gas, and echocardiographic parameters during 24-h levosimendan infusion.
| Before 0 h (n=15) | 6 h (n=15) | 12 h (n=15) | 24 h (n=15) | p | |
|---|---|---|---|---|---|
| Heart rate (bpm) | 162 (111–175) | 139 (114–163) | 127 (104–151) | 132 (99–148)a | 0.02 |
| Systolic pressure (mmHg) | 79 (68–90) | 89 (82–100) | 91 (83–101)b | 98 (89–109)a | <0.001 |
| Diastolic pressure (mmHg) | 47 (40–57) | 55 (47–65) | 61 (53–67) | 66 (54–76)a | <0.001 |
| pH | 7.36 (7.29–7.44) | 7.4 (7.35–7.43) | 7.46 (7.39–7.50)b | 7.45 (7.38–7.48) | 0.04 |
| Lactate (mmol/L) | 4.15 (2.3–6.5) | 1.85 (0.8–2.6)c | 1.0 (0.8–1.85) | 1.04 (0.8–1.45) | <0.001 |
| pCO 2 (mmHg) | 44 (29–49) | 45 (36–48) | 39 (33–42) | 40 (35–46) | 0.39 |
| Urine output (mL/kg/h) | 3.2 (1.8–5.07) | _ | _ | 4.2 (2.7–5.2) | 0.09 |
| LV ejection fraction, % | 45±14.8 | _ | _ | 58±15.6a | <0.001 |
| Vasoactive inotropic score | 60 (40–90) | 55 (40–80) | 0.11 |
Data are presented as mean ± SD or as median (25th–75th percentile), as appropriate. Notations a, b, and c indicate statistically significant differences: (a) between baseline and 24 h, (b) between baseline and 12 h, and (c) between baseline and 6 h, respectively. Statistically significant p-values are highlighted in bold.