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. 2024 Apr 8;13(8):e030895. doi: 10.1161/JAHA.123.030895

Table 3.

Age‐Adjusted Mortality Rate for Valvular Heart Disease With Its Subtypes in 1999 and 2020, and Average Annual Percent Change by Age Group

Diseases Overall 15–64 years old ≥65 years old
1999 AAMR 2020 AAMR Average annual percent change, (95% CI) 1999 AAMR 2020 AAMR Average annual percent change, (95% CI) % 1999 AAMR 2020 AAMR Average annual percent change, (95% CI) %
Valvular heart diseases 8.36 (8.24 to 8.48) 6.61 (6.52 to 6.70) −0.75 (−0.97 to −0.52) 1.07 (1.02 to 1.11) 0.88 (0.84 to 0.92) −0.96 (−1.61 to −0.31) 46.38 (45.66 to 47.10) 36.45 (35.93 to 36.97) −0.73 (−1.00 to −0.45)
Aortic regurgitation 0.29 (0.26 to 0.31) 0.19 (0.17 to 0.20) −1.89 (−2.94 to −0.83) 0.06 (0.05 to 0.07) 0.05 (0.04 to 0.06) 0.14 (−2.24 to 2.59) 1.47 (1.35 to 1.60) 0.91 (0.83 to 0.99) −2.41 (−3.30 to −1.50)
Aortic stenosis 4.65 (4.56 to 4.75) 3.95 (3.88 to 4.02) −0.17 (−0.61 to 0.26) 0.22 (0.20 to 0.24) 0.19 (0.18 to 0.21) −0.06 (−0.78 to 0.66) 27.77 (27.22 to 28.33) 23.52 (23.10 to 23.93) −0.18 (−0.64 to 0.28)
Mitral regurgitation 1.29 (1.24 to 1.34) 0.77 (0.74 to 0.80) −2.47 (−2.99 to −1.96) 0.23 (0.21 to 0.25) 0.13 (0.12 to 0.15) −2.97 (−3.56 to −2.37) 6.79 (6.51 to 7.06) 4.08 (3.91 to 4.25) −2.39 (−2.91 to −1.86)
Mitral stenosis 0.40 (0.37 to 0.42) 0.21 (0.19 to 0.23) −2.37 (−4.00 to −0.72) 0.12 (0.10 to 0.14) 0.05 (0.04 to 0.06) −4.61 (−8.46 to −0.59) 1.84 (1.70 to 1.98) 1.06 (0.97 to 1.14) −1.80 (−3.1 to −0.5)

AAMR indicates age‐adjusted mortality rate.