Comparison 1. Chlorhexidine (vaginal wash or gel/cream) versus placebo or no treatment.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Early onset GBS disease (sepsis and/or meningitis within the first seven days of life))	2	987	Risk Ratio (M‐H, Fixed, 95% CI)	2.32 [0.34, 15.63]
2 GBS pneumonia within the first seven days of life	2	987	Risk Ratio (M‐H, Fixed, 95% CI)	0.35 [0.01, 8.60]
3 Neonatal colonization with GBS within the first seven days of life	3	328	Risk Ratio (M‐H, Random, 95% CI)	0.65 [0.36, 1.18]
4 Neonatal mortality due to early‐onset GBS infection	1	190	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
5 Adverse (mild) effects in the mother	3	1066	Risk Ratio (M‐H, Fixed, 95% CI)	8.50 [1.60, 45.28]
6 Adverse (mild) effects in the neonate	3	1066	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]