Table 1. Descriptive statistics of the study population stratified according to the 2012 Briganti nomogram score predicting the risk of lymph node invasion (up to the median vs above the median (*), and logistic regression models of association of clinical and pathological factors with a 2012 Briganti nomogram risk score >6%.
| Overall cohort | Briganti nomogram risk score ≤ 6% | Briganti nomogram risk score > 6% | Univariable | Multivariable (*) | |||
|---|---|---|---|---|---|---|---|
| n = 147 | n = 75 (51.1) | n = 72 (48.9) | OR (95% CI) | P-value | OR (95% CI) | P-value | |
| Age (years) | 66 (61 – 71) | 69 (62 - 72) | 65 (61 - 70) | 0.94 (0.88 - 0.99) | 0.026 | 0.91 (0.85 - 0.98) | 0.016 |
| BMI (kg/m^2) | 25.6 (23.7 - 27.9) | 25.9 (23.9 - 27.8) | 25.6 (23.1 - 28.3) | 1.01 (0.91 - 1.11) | 0.9 | ||
| ASA | |||||||
| 1 | 10 (6.8) | 5 (6.7) | 5 (6.9) | Ref. | - | ||
| 2 | 129 (81.6) | 60 (80.0) | 60 (83.3) | 1 (0.28 - 3.63) | 1.0 | ||
| 3 | 17 (11.6) | 10 (13.3) | 7 (9.8) | 0.70 (0.15 - 3.37) | 0.7 | ||
| PV (mL) | 36.5 (29.0 - 46.0) | 38.1 (30.0 - 50.0) | 34.0 (28.0 - 45.0) | 0.99 (0.96 - 1.01) | 0.2 | ||
| PSA (ng/mL) | 6.3 (5.0 - 8.0) | 5.6 (4.9 - 7.3) | 6.8 (5.2 - 8.5) | 1.24 (1.03 - 1.45) | 0.022 | ||
| BPC (%) | 31.2 (20.0 - 50.0) | 20.0 (14.2 - 28.5) | 48.6 (33.3 - 66.1) | 1.11 (1.07 - 1.15) | <0.001 | 1.11 (1.07 - 1.15) | <0.001 |
| Clinical stage | |||||||
| T1c | 74 (52.1) | 51 (68.0) | 26 (36.1) | Ref. | - | Ref. | - |
| T2b | 68 (47.9) | 24 (32.0) | 46 (63.9) | 3.76 (1.90 - 7.44) | <0.001 | 2.99 (1.15 - 7.77) | 0.024 |
| PW (gr) | 50.0 (42.0 - 60.0) | 50.0 (43.0 - 63.0) | 48.5 (40.2 - 60.0) | 0.99 (0.96 - 1.01) | 0.2 | ||
| Tumor upgrade | |||||||
| No (ISUP ≤3) | 107 (72.8) | 62 (82.7) | 45 (62.5) | Ref. | - | Ref. | - |
| Yes (ISUP >3) | 40 (27.2) | 13 (17.3) | 27 (37.5) | 2.86 (1.33 - 6.15) | 0.007 | 3.36 (1.07 - 10.61) | 0.039 |
| Tumor stage | |||||||
| pT2 (organ confined) | 115 (78.2) | 66 (88.0) | 49 (68.1) | Ref. | - | ||
| pT3 (non-organ confined) | 32 (21.8) | 9 (12.0) | 23 (31.9) | 3.44 (1.47 - 8.09) | 0.005 | ||
| Surgical margins | |||||||
| Negative (R0) | 123 (83.7) | 70 (93.3) | 53 (73.6) | Ref. | - | ||
| Positive (R1) | 24 (16.3) | 5 (6.7) | 19 (26.4) | 5.02 (1.76 - 14.31) | 0.003 | ||
Abbreviations: OR = odds ratio; CI = confidence interval; BMI = body mass index; ASA = American Society of Anesthesiologists; PV = prostate volume; PSA = prostate-specific antigen; BPC = biopsy positive cores; PW = prostate weight; ISUP = International Society of Urological Pathology.
Continuous variables are reported as median (interquartile range) while categorical factors as frequencies (percentage).