Figure 2. Surgical steps to create critical bone defect and implantation of biomaterial. (a) bicoronal semilunar skin incision; (b) detachment and removal of periosteum; (c) exposed osseous tissue; (d) critical bone defect made by trephine drill; (e) critical bone defect; (f) implantation of biomaterial; and (g) skin tissue flap repositioned and sutured in simple interrupted pattern.