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. 2024 Jun 14;65(4):482–490. doi: 10.1093/jrr/rrae044

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© The Author(s) 2024. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 2 — Phase-separated BRD4-IDRs minimize the DNA damage in vitro. (A) BRD4-IDRs were diluted in the buffer to a final concentration of 5 μM in the presence of DNA (5 ng/μl) and indicated conditions. Colocalization in ROI was visualized using nMDP colormap. (B) BRD4-IDRs and DNA were diluted in the buffer to a final concentration of 5 μM and indicated conditions in the presence of 10% PEG. (C) The extent of colocalization was quantified using nMDP value and visualized by density plot. (D) Result of DNA damage represented in the presence of BRD4-IDRs with/without 10% PEG. (E) Heatmap visualization of the extent of DNA amounts. Maximum signal of DNA (non-damaged DNA) was prepared as 100%.