TABLE 1.

Benefits of comprehensive genomic profiling in oncology.

Hallmark	Key aspects
Personalized Medicine	By providing a detailed genetic profile of a tumor, CGP supports the implementation of personalized medicine, where treatments are tailored to the unique characteristics of each patient’s cancer
Improved Treatment Outcomes	Patients who receive therapy based on CGP findings can often experience better outcomes, including higher response rates, longer progression-free survival, and, in some cases, improved overall survival
Cost-Effectiveness	Although initially more expensive than single-gene tests, CGP can be more cost-effective in the long term by identifying the most effective therapy from the outset, reducing the need for trial-and-error treatment approaches
Identification of Resistance Mechanisms	CGP can uncover genetic alterations that confer resistance to certain treatments, guiding clinicians in selecting alternative therapies or combination strategies to overcome resistance
Challenges and Considerations on CGP	Despite its advantages, CGP faces challenges, including the need for sufficient tumor tissue samples, the complexity of data interpretation, and the requirement for specialized bioinformatics support to analyze and understand the results. Additionally, there are ongoing discussions regarding the reimbursement and cost coverage of CGP tests by healthcare systems and insurance providers

CGP: comprehensive genomic profiling.