Table 1.
Baseline characteristics comparison between patients with PD who are treated with low dose or high dose of anti-PD oral medications
| Characteristic | Low dose (n = 2233) |
High dose (n = 292) |
p value |
|---|---|---|---|
| Age at first PD indication, years | |||
| Mean (SD) | 74.4 (10.9) | 75.4 (8.8) | 0.074 |
| Median (IQR) | 75.9 (68.5–82.1) | 75.8 (72–81.3) | |
| Range | 23.1–101.8 | 31.3–94.3 | |
| < 75 | 1040 (46.6) | 130 (44.5) | 0.274 |
| ≥ 75 | 1193 (53.4) | 162 (55.5) | |
| Sex | |||
| Male | 1222 (54.7) | 190 (65.1) | < 0.001 |
| Female | 1011 (45.3) | 102 (34.9) | |
| Cardiovascular disease | 624 (27.9) | 89 (30.5) | 0.201 |
| Hypertension | 1634 (73.2) | 229 (78.4) | 0.031 |
| Cerebrovascular disease | 184 (8.2) | 23 (7.9) | 0.47 |
| Diabetes | 644 (28.8) | 95 (32.5) | 0.109 |
| Chronic kidney disease | 1349 (60.4) | 176 (60.3) | 0.506 |
| Anxiety/depression/mood disorders | 935 (41.9) | 114 (39.0) | 0.195 |
| Mild cognitive impairment/dementia | 295 (13.2) | 34 (11.6) | 0.259 |
| Constipation | 555 (24.9) | 63 (21.6) | 0.124 |
| Psychosis | 121 (5.4) | 18 (6.2) | 0.339 |
| Urinary symptoms | 402 (18.0) | 43 (14.7) | 0.095 |
| Sexual problems | 87 (3.9) | 15 (5.1) | 0.193 |
| Dysphagia | 67 (3.0) | 3 (1.0) | 0.03 |
| Orthostatic hypotension | 21 (0.9) | 3 (1.0) | 0.537 |
| Tremor | 471 (21.1) | 45 (15.4) | 0.013 |
| Gait abnormalities | 184 (8.2) | 46 (15.8) | < 0.001 |
| First fall | 481 (21.5) | 64 (21.9) | 0.467 |
Data are presented as n (%) unless otherwise noted
IQR interquartile range, PD Parkinson’s disease