Table 1.
Patient characteristics (safety analysis set)
| Characteristic | Safety analysis set (N = 821)a |
|---|---|
| Age, years | |
| Median (range) | 53 (4–75) |
| Mean ± SD | 49.75 ± 14.32 |
| Unknown | 14 (1.71) |
| Sex | |
| Male | 486 (59.20) |
| Female | 335 (40.80) |
| Number of transplants | |
| 1 | 670 (81.61) |
| ≥2 | 149 (18.15) |
| Unknown | 2 (0.24) |
| Length of hospital stay after first transplantation, daysb | |
| Median (range) | 87.0 (17–482) |
| Mean ± SD | 102.3 ± 57.1 |
| Unknown | 28 (3.41) |
| Primary reason for HSCT | |
| Acute myeloid leukemia | 311 (37.88) |
| Acute lymphoblastic leukemia | 155 (18.88) |
| Myelodysplastic syndrome | 116 (14.13) |
| Lymphoid malignant tumor | 105 (12.79) |
| Other diseases | 133 (16.20) |
| CMV antibody combination | |
| R+/D+ | 287 (34.96) |
| R+/D− | 273 (33.25) |
| R−/D+ | 39 (4.75) |
| R−/D− | 32 (3.90) |
| Unknown | 190 (23.14) |
| Stem cell source | |
| Cord blood | 283 (34.47) |
| Bone marrow | 277 (33.74) |
| Peripheral blood | 259 (31.55) |
| Donor type | |
| Allogeneic transplantation | 818 (99.63) |
| Related | 243 (29.60) |
| Sibling | 147 (17.90) |
| Other sibling | 88 (10.72) |
| Unrelated | 575 (70.04) |
| Autologous transplantation | 1 (0.12) |
| Unknown | 2 (0.24) |
| HLA | |
| Matched | 266 (32.40) |
| Mismatched | 527 (64.19) |
| Mismatched excluding haploidentical | 417 (50.79) |
| Haploidentical | 110 (13.40) |
| Other | 2 (0.24) |
| Unknown | 26 (3.17) |
| Conditioning regimen | |
| Myeloablative transplantation | 389 (47.38) |
| Anti-thymocyte globulin | 140 (17.05) |
| T-cell depletion or CD34(+) selected HSCT | 9 (1.10) |
| Pre-transplantation corticosteroid use | 390 (47.50) |
| GVHD prophylaxis | |
| Yes | 795 (96.83) |
| No | 2 (0.24) |
| Unknown | 24 (2.92) |
| Drugs used for GVHD prophylaxis (>5%)c | |
| Tacrolimus | 646 (78.68) |
| Methotrexate | 598 (72.84) |
| Mycophenolate mofetil | 163 (19.85) |
| Cyclosporine | 139 (16.93) |
| Cyclophosphamide | 58 (7.06) |
HSCT hematopoietic stem cell transplantation, GVHD graft versus host disease