Table 3.
Administration of letermovir (safety analysis set; N = 821)
| Category | Valuea |
|---|---|
| Letermovir dose and cyclosporine useb | |
| Letermovir 480 mg without cyclosporine | 624 (76.00) |
| Letermovir 240 mg without cyclosporine | 53 (6.46) |
| Letermovir 480 mg with cyclosporine | 5 (0.61) |
| Letermovir 240 mg with cyclosporine | 136 (16.57) |
| Dosage form | |
| Oral tablet only | 594 (72.35) |
| IV only | 29 (3.53) |
| Switched between dosage forms | 196 (23.87) |
| Timing of the first dose | |
| Median (range), day | 2.0 (−10 to 100) |
| Before transplantation | 10 (1.22) |
| On day 1c | 334 (40.68) |
| After transplantation | |
| Between days > 1 and ≤ 7 | 219 (26.67) |
| Between days > 7 and ≤ 14 | 145 (17.66) |
| Between days > 14 and ≤ 30 | 94 (11.45) |
| Between days > 30 and ≤ 60 | 10 (1.22) |
| Between days > 60 and ≤ 90 | 6 (0.73) |
| After day > 90 | 1 (0.12) |
| Administration period | |
| By administration route, median (range), days | |
| Overall | 83.0 (1–521) |
| Oral tablet | 72.0 (1–349) |
| IV | 21.0 (1–117) |
| Duration of administration, days | |
| ≤10 | 65 (7.92) |
| > 10 to ≤ 40 | 143 (17.42) |
| > 40 to ≤ 70 | 128 (15.59) |
| > 70 to ≤ 100 | 370 (45.07) |
| > 100 to ≤ 200 | 108 (13.15) |
| > 200 | 5 (0.61) |
IV intravenous
aValues are n (%) of patients unless otherwise specified
bAt the start of letermovir treatment
cDay of transplantation