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. 2024 Jul 22;15(7):521. doi: 10.1038/s41419-024-06894-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Dot plots of Hallmark gene sets indicating the regulation of the indicated pathways organized by the process. Each column represents the comparison listed at the bottom in the respective models. The size of each dot corresponds to the level of significance, whereby larger dots indicate greater significance of the gene set enrichment. The color of the dots represents the type of regulation: red for upregulation and blue for down-regulation. Only darkly colored dots are considered statistically significant, whereas dots with lighter colors are not statistically significant. B Heatmap of the significant genes of the ‘COMBO_2h vs CTR’ and ‘COMBO_24h vs CTR’ comparisons, respectively, considering the two models together.