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. 2024 Jul 22;15(7):522. doi: 10.1038/s41419-024-06902-4

Fig. 8. Erianin inhibits tumor formation of TMZ-resistant GSCs in vivo.

Fig. 8

Bioluminescence imaging (a) and quantification (b) of luciferase intensity in GSCm01R xenografted nude mice treated with multiple groups (DMSO, TMZ, TMZ + Erianin, TMZ + Erianin + REST-EV, TMZ + Erianin + REST-OE, TMZ + Erianin + SLC40A1-EV, TMZ + Erianin + SLC40A1-OE). c Kaplan–Meier survival analysis illustrates the survival times of GSCm01R xenografted nude mice of different mentioned treatment groups. d–f qPCR assays showing the expression of REST, SLC40A1, and Ki-67 in the above-mentioned multiple groups. g Schematic diagram illustrating erianin inducing ferroptosis in TMZ-resistant GSCs through REST/LRSAM1 mediated ubiquitination degradation of SLC40A1. h Representative H&E and immunohistochemical images showed the staining and expression of REST, LRSAM1, SLC40A1 and Ki-67 of the multiple groups mentioned above. Scale bar = 50 μm. All data are shown as the mean ± SD (five independent experiments). *p < 0.05; **p < 0.01; ***p < 0.001; ns, no significance.