Table 1.
Comparison of caspases in different species with focus on classical caspase categorisation. In category „others“ the caspase either does not fit groups above or have not yet been specified. * differentiation of keratinocytes [259], **regulates non-canonical pathway of apoptosis [291], *** blocks CED-3 and apoptosis in germ cells [292], **** blocks CED-3 and apoptosis in somatic cells [292]
| human | mouse M. musculus |
zebrafish D. rerio |
fruitfly D. melanogaster |
worm C. elegans |
|
|---|---|---|---|---|---|
| number of caspases | 13 | 11 | 19 | 7 | 4 |
| inflammatory caspases | -1, -4, -5 -12 | -1, -11, -12 | -1, -19a, -19b, -23 | ||
| initiator caspases | -2, -8, -9, -10 | -2, -8, -9 | -2, -8a, -8b, -9, -10, -20, -22 | Dredd, Dronc, Strica | |
| executor caspases | -3, -6, -7 | -3, -6, -7 | -3a, -3b, -6a, -6b, -6c,-7, -21 | Drice, Dcp-1, Decay, Dam | CED-3 |
| others | -14*, -16 | -14*, − 16 | -17 | CSP-1**, CSP-2***, and CSP-3**** | |
| references | [15] | [15] | [293] | [294] | [19] |