Table 6.

Phenotypes of mice lacking caspase-14

	mouse strain	development/ phenotype	apoptotic/ non-apoptotic/unspecified effect	reference
Casp-14 −/−	Swiss Webster X 129	shinier and more lichenified skin	abnormal cleavage of profilaggrin	[266]
Casp-14 −/−	Swiss Webster X 129	reduced epidermal barrier	defect in the terminal filaggrin degradation	[260]
Casp-14 −/−	Swiss Webster X 129	predisposed parakeratosis	abnormal differentiation and the maintenance of stratum corneum	[268]
Casp-14 −/−	Swiss Webster X 129	enhanced antibacterial response	imbalance of the skin-resident bacterial communities	[269]