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. Author manuscript; available in PMC: 2025 Aug 1.
Published in final edited form as: Trends Microbiol. 2024 Jan 23;32(8):781–790. doi: 10.1016/j.tim.2024.01.001

Figure 1. Protein domain organization of cleavage and polyadenylation specificity factor subunit 6 (CPSF6).

Figure 1.

The various domains and functions of human CPSF6. The amino acid (aa) positions for each large domain are shown: RNA-recognition motif in orange (aa 81–157); proline-rich domain in yellow (aa 208–398); and arginine-serine-like domain (RSLD) in red (aa 489–551). Additional interaction motifs are shown in green: CPSF5 interaction motif (aa 116–122), glycine/arginine-rich domain (aa 202–206), the HIV-1 capsid interaction motif (aa 276–290), and the transportin 1 (TNPO1) interaction motif (aa 362–390).