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. 2024 Jun 27;13(4):1273–1285. doi: 10.1007/s40120-024-00637-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 1 — a Adjusted ARR^a on treatment compared with baseline and b patients with no relapses from baseline to week 96. “Without lymphopenia” is defined as all ALCs remained ≥ LLN. “With lymphopenia” is defined as ≥ 1 ALC below the LLN at any time during the study.^aCalculation of ARR was based on patient-reported relapses in the 12 months before study entry compared with protocol-defined relapses during the study period. Adjusted ARR was based on a Poisson regression model adjusted for treatment duration. ^bBaseline is the 12 months prior to study entry. ALC absolute lymphocyte count, ARR annualized relapse rate, CI confidence interval, LLN lower limit of normal (ALC = 0.91 × 10⁹/L)