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. 2024 Jul 23;7:892. doi: 10.1038/s42003-024-06581-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Osteoblast-specific, but not osteoclasts, depletion of Hif1a in Hif1a^fl/fl;Col1a1-Cre mice and their wild-type littermates, Hif1a^fl/fl was verified by immunohistochemistry with anti-HIF-1α antibody (n = 3). The arrows indicate osteoclasts, and the dotted line indicates osteoblasts. GP, growth plate; BM, bone marrow; TB, trabecula bone; CB, cortical bone. Scale bar, 25 μm. b μCT images of femurs captured by the transverse (top), sagittal (middle), and coronal (bottom) planes. Red boxes indicate regions of interest. c Representative images of μCT reconstructions of trabecular bones and quantitative analyses of BMD, BV/TV, Tb.Th, Tb.Sp, and Tb.N of femora (n = 8). d H&E staining results and bone histomorphometric analysis, including BV/TV, N.Ob/B.Pm, and Ob.S/BS (n = 8). Scale bar, 100 μm. Values are presented as the mean ± SEM. Unpaired t-test was performed. *P < 0.05, **P < 0.01, and ***P < 0.001.