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Example of a potential stem-loop structure identified by covariance screening of 17 HGV/GBV-C sequences of genotypes 1 to 3. Covariant sites are indicated by numbering. Analogous structures were detected by analysis of type 3 sequences only (data not shown). All changes from consensus nucleotide sequence were synonymous except for those marked in bold. Vertical lines indicate Watson-Crick base pairing; asterisks indicate GU base pairing.
