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. 2024 Jul 5;27:101147. doi: 10.1016/j.mtbio.2024.101147

Fig. 6.

Fig. 6

The BMC + L promoted cranial bone regeneration.

(A) Schematic diagram of BMC + L treatment for mouse cranial bone defects. (B) Representative micro-CT images of calvarial defects with different treatments at 4 and 8 weeks after surgery. Scale bar = 2 mm. (C) The BV/TV, BMD, Tb. N, and Tb. Th. of the newly formed bone of all groups at week 4 after various treatments. (D) H&E, Masson, and OPN staining of calvarial bone defects from mice at week 4 after various treatments. Scale bar = 200 μm. (E) IL6 and IL10 staining of calvarial bone defects from mice at week 2 after various treatments. Scale bar = 200 μm. (F) Piezo1 fluorescence staining of calvarial bone defects from mice at week 2 after various treatments. Scale bar = 200 μm. L, LIPUS stimulation; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.