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. 2024 Jul 23;3(7):e167. doi: 10.1002/jex2.167

TABLE 2.

List of proteins enriched by UC3 or UC2‐qEV in comparison to UC2.

Symbol Entrez gene name Symbol Entrez gene name
ABCB6 ATP binding cassette subfamily B member 6 (Langereis blood group) KIF5B kinesin family member 5B
ABCC1 ATP binding cassette subfamily C member 1 KLC1 kinesin light chain 1
ABCC4 ATP binding cassette subfamily C member 4 KPNB1 karyopherin subunit beta 1
ABCC5 ATP binding cassette subfamily C member 5 KRAS KRAS proto‐oncogene, GTPase
ACTB actin beta LAMP2 lysosomal associated membrane protein 2
ACTBL2 actin beta like 2 LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
ACTC1 actin alpha cardiac muscle 1 LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
ACTR1A actin related protein 1A LAP3 leucine aminopeptidase 3
ACTR2 actin related protein 2 LASP1 LIM and SH3 protein 1
ACVR1 activin A receptor type 1 LCN1 lipocalin 1
ADAM17 ADAM metallopeptidase domain 17 LCN2 lipocalin 2
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide LCP1 lymphocyte cytosolic protein 1
AGO2 argonaute RISC catalytic component 2 LGALS3 galectin 3
AHCY adenosylhomocysteinase LHFPL2 LHFPL tetraspan subfamily member 2
AHNAK AHNAK nucleoprotein LMBRD2 LMBR1 domain containing 2
AHSP alpha hemoglobin stabilizing protein LNPEP leucyl and cystinyl aminopeptidase
AK1 adenylate kinase 1 LRRC8D leucine rich repeat containing 8 VRAC subunit D
ALOX12 arachidonate 12‐lipoxygenase, 12S type LRSAM1 leucine rich repeat and sterile alpha motif containing 1
ALPL alkaline phosphatase, biomineralization associated LSM4 LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
AMPD2 adenosine monophosphate deaminase 2 MARCHF8 membrane associated ring‐CH‐type finger 8
ANK1 ankyrin 1 MARCKSL1 MARCKS like 1
ANPEP alanyl aminopeptidase, membrane MBP myelin basic protein
ANXA1 annexin A1 MDH1 malate dehydrogenase 1
ANXA11 annexin A11 MDH2 malate dehydrogenase 2
ANXA2 annexin A2 MFGE8 milk fat globule EGF and factor V/VIII domain containing
ANXA4 annexin A4 MGLL monoglyceride lipase
ANXA6 annexin A6 MINK1 misshapen like kinase 1
AP1B1 adaptor related protein complex 1 subunit beta 1 MME membrane metalloendopeptidase
AP1G1 adaptor related protein complex 1 subunit gamma 1 MPP1 MAGUK p55 scaffold protein 1
AP1M1 adaptor related protein complex 1 subunit mu 1 MSN Moesin
AP2M1 adaptor related protein complex 2 subunit mu 1 MVP major vault protein
APRT adenine phosphoribosyltransferase MYO1G myosin IG
AQP1 aquaporin 1 (Colton blood group) NAP1L4 nucleosome assembly protein 1 like 4
ARF6 ADP ribosylation factor 6 NAPG NSF attachment protein gamma
ARHGAP1 Rho GTPase activating protein 1 NCKAP1 NCK associated protein 1
ARHGAP17 Rho GTPase activating protein 17 NCKAP1L NCK associated protein 1 like
ARHGAP18 Rho GTPase activating protein 18 NECTIN2 nectin cell adhesion molecule 2
ARPC2 actin related protein 2/3 complex subunit 2 NME1‐NME2 NME1‐NME2 readthrough
ARPC5 actin related protein 2/3 complex subunit 5 NPEPPS aminopeptidase puromycin sensitive
ATIC 5‐aminoimidazole‐4‐carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase NPTN neuroplastin
ATP11B ATPase phospholipid transporting 11B (putative) NRAS NRAS proto‐oncogene, GTPase
ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 NRGN neurogranin
ATP1B3 ATPase Na+/K+ transporting subunit beta 3 NSF N‐ethylmaleimide sensitive factor, vesicle fusing ATPase
ATP5F1A ATP synthase F1 subunit alpha NT5E 5′‐nucleotidase ecto
ATP5F1B ATP synthase F1 subunit beta NUTF2 nuclear transport factor 2
ATP6AP1 ATPase H+ transporting accessory protein 1 OLFM4 olfactomedin 4
ATP6V0A2 ATPase H+ transporting V0 subunit a2 OXSR1 oxidative stress responsive kinase 1
ATP6V1A ATPase H+ transporting V1 subunit A P2RY12 purinergic receptor P2Y12
ATP6V1B2 ATPase H+ transporting V1 subunit B2 PACSIN2 protein kinase C and casein kinase substrate in neurons 2
ATP6V1E1 ATPase H+ transporting V1 subunit E1 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
ATP6V1G1 ATPase H+ transporting V1 subunit G1 PARK7 Parkinsonism associated deglycase
ATP6V1H ATPase H+ transporting V1 subunit H PDCD6 programmed cell death 6
ATP7A ATPase copper transporting alpha PDCD6IP programmed cell death 6 interacting protein
BAG2 BAG cochaperone 2 PDE5A phosphodiesterase 5A
BAIAP2 BAR/IMD domain containing adaptor protein 2 PDIA6 protein disulfide isomerase family A member 6
BCAM basal cell adhesion molecule (Lutheran blood group) PDLIM1 PDZ and LIM domain 1
BLMH bleomycin hydrolase PEA15 proliferation and apoptosis adaptor protein 15
BLVRA biliverdin reductase A PEBP1 phosphatidylethanolamine binding protein 1
BLVRB biliverdin reductase B PFKP phosphofructokinase, platelet
BROX BRO1 domain and CAAX motif containing PGAM1 phosphoglycerate mutase 1
BTK Bruton tyrosine kinase PGD phosphogluconate dehydrogenase
C2orf88 chromosome 2 open reading frame 88 PGK1 phosphoglycerate kinase 1
CA1 carbonic anhydrase 1 PGRMC1 progesterone receptor membrane component 1
CA2 carbonic anhydrase 2 PI4K2A phosphatidylinositol 4‐kinase type 2 alpha
CALM1 (includes others) calmodulin 1 PIP prolactin induced protein
CALR calreticulin PIP4K2A phosphatidylinositol‐5‐phosphate 4‐kinase type 2 alpha
CAND1 cullin associated and neddylation dissociated 1 PKM pyruvate kinase M1/2
CANX calnexin PLS3 plastin 3
CAPN5 calpain 5 PLSCR1 phospholipid scramblase 1
CCL5 C‐C motif chemokine ligand 5 PLXNA4 plexin A4
CCRL2 C‐C motif chemokine receptor like 2 PLXNB2 plexin B2
CCT5 chaperonin containing TCP1 subunit 5 PLXNB3 plexin B3
CCT7 chaperonin containing TCP1 subunit 7 PNP purine nucleoside phosphorylase
CD109 CD109 molecule PODXL podocalyxin like
CD2 CD2 molecule PPBP pro‐platelet basic protein
CD2AP CD2 associated protein PPIA peptidylprolyl isomerase A
Symbol Entrez Gene Name Symbol Entrez Gene Name
CD3E CD3 epsilon subunit of T‐cell receptor complex PPIB peptidylprolyl isomerase B
CD44 CD44 molecule (Indian blood group) PPIF peptidylprolyl isomerase F
CD46 CD46 molecule PPM1A protein phosphatase, Mg2+/Mn2+ dependent 1A
CD47 CD47 molecule PPP1R21 protein phosphatase 1 regulatory subunit 21
CD48 CD48 molecule PRDX5 peroxiredoxin 5
CD5 CD5 molecule PRKACA protein kinase cAMP‐activated catalytic subunit alpha
CD55 CD55 molecule (Cromer blood group) PRKACB protein kinase cAMP‐activated catalytic subunit beta
CD58 CD58 molecule PRPS1 phosphoribosyl pyrophosphate synthetase 1
CD6 CD6 molecule PSMB1 proteasome 20S subunit beta 1
CD69 CD69 molecule PSMB10 proteasome 20S subunit beta 10
CD81 CD81 molecule PSMB3 proteasome 20S subunit beta 3
CD82 CD82 molecule PSME1 proteasome activator subunit 1
CD84 CD84 molecule PSTPIP2 proline‐serine‐threonine phosphatase interacting protein 2
CD9 CD9 molecule PTGES3 prostaglandin E synthase 3
CDC37 cell division cycle 37, HSP90 cochaperone PTGS1 prostaglandin‐endoperoxide synthase 1
CDC42 cell division cycle 42 PTMA prothymosin alpha
CFL1 cofilin 1 PTP4A2 protein tyrosine phosphatase 4A2
CHMP2A charged multivesicular body protein 2A PTPN23 protein tyrosine phosphatase non‐receptor type 23
CHMP2B charged multivesicular body protein 2B PTPRA protein tyrosine phosphatase receptor type A
CHMP4A charged multivesicular body protein 4A RAB11B RAB11B, member RAS oncogene family
CHMP4B charged multivesicular body protein 4B RAB14 RAB14, member RAS oncogene family
CHMP5 charged multivesicular body protein 5 RAB21 RAB21, member RAS oncogene family
CIB1 calcium and integrin binding 1 RAB2A RAB2A, member RAS oncogene family
CLC Charcot‐Leyden crystal galectin RAB2B RAB2B, member RAS oncogene family
CLEC1B C‐type lectin domain family 1 member B RAB35 RAB35, member RAS oncogene family
CLEC4M C‐type lectin domain family 4 member M RAB7A RAB7A, member RAS oncogene family
CLIC1 chloride intracellular channel 1 RAB8A RAB8A, member RAS oncogene family
CLIC2 chloride intracellular channel 2 RAB8B RAB8B, member RAS oncogene family
CLIC4 chloride intracellular channel 4 RABEP1 rabaptin, RAB GTPase binding effector protein 1
CLINT1 clathrin interactor 1 RAC1 Rac family small GTPase 1
CMIP c‐Maf inducing protein RAC2 Rac family small GTPase 2
CNDP2 carnosine dipeptidase 2 RALB RAS like proto‐oncogene B
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 RAN RAN, member RAS oncogene family
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 RAP1A RAP1A, member of RAS oncogene family
CNP 2′,3′‐cyclic nucleotide 3′ phosphodiesterase RAP1B RAP1B, member of RAS oncogene family
COL6A3 collagen type VI alpha 3 chain RAP2B RAP2B, member of RAS oncogene family
CORO1B coronin 1B RAP2C RAP2C, member of RAS oncogene family
COTL1 coactosin like F‐actin binding protein 1 RASGRP2 RAS guanyl releasing protein 2
CPNE1 copine 1 RDX radixin
CRIP1 cysteine rich protein 1 REEP5 receptor accessory protein 5
CRIP2 cysteine rich protein 2 RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase
CRKL CRK like proto‐oncogene, adaptor protein RFTN1 raftlin, lipid raft linker 1
CRYZL1 crystallin zeta like 1 RGS18 regulator of G protein signaling 18
CS citrate synthase RHAG Rh associated glycoprotein
CSK C‐terminal Src kinase RHCE/RHD Rh blood group D antigen
CTSA cathepsin A RHOA ras homolog family member A
CYBRD1 cytochrome b reductase 1 RHOF ras homolog family member F, filopodia associated
CYC1 cytochrome c1 ROCK2 Rho associated coiled‐coil containing protein kinase 2
CYCS cytochrome c, somatic S100A10 S100 calcium binding protein A10
CYRIB CYFIP related Rac1 interactor B S100A11 S100 calcium binding protein A11
DAAM1 dishevelled associated activator of morphogenesis 1 S100A7 S100 calcium binding protein A7
DBI diazepam binding inhibitor, acyl‐CoA binding protein S100A9 S100 calcium binding protein A9
DBNL drebrin like SCAMP2 secretory carrier membrane protein 2
DCD dermcidin SDCBP syndecan binding protein
DDAH2 dimethylarginine dimethylaminohydrolase 2 SEC24C SEC24 homolog C, COPII coat complex component
DDT D‐dopachrome tautomerase SELL selectin L
DERA deoxyribose‐phosphate aldolase SELP selectin P
DNAJA2 DnaJ heat shock protein family (Hsp40) member A2 SEMA7A semaphorin 7A (John Milton Hagen blood group)
DNAJA4 DnaJ heat shock protein family (Hsp40) member A4 SEPTIN11 septin 11
DNAJB1 DnaJ heat shock protein family (Hsp40) member B1 SEPTIN6 septin 6
DNAJB4 DnaJ heat shock protein family (Hsp40) member B4 SERINC3 serine incorporator 3
DNAJC5 DnaJ heat shock protein family (Hsp40) member C5 SERPINB9 serpin family B member 9
DNAJC7 DnaJ heat shock protein family (Hsp40) member C7 SKP1 S‐phase kinase associated protein 1
DNM1 dynamin 1 SLC11A2 solute carrier family 11 member 2
DOCK10 dedicator of cytokinesis 10 SLC12A4 solute carrier family 12 member 4
DPP4 dipeptidyl peptidase 4 SLC12A6 solute carrier family 12 member 6
DPYSL2 dihydropyrimidinase like 2 SLC12A7 solute carrier family 12 member 7
DYNLL2 dynein light chain LC8‐type 2 SLC16A1 solute carrier family 16 member 1
ECE1 endothelin converting enzyme 1 SLC16A7 solute carrier family 16 member 7
EFR3A EFR3 homolog A SLC1A4 solute carrier family 1 member 4
EHD1 EH domain containing 1 SLC1A5 solute carrier family 1 member 5
EIF5A eukaryotic translation initiation factor 5A SLC22A16 solute carrier family 22 member 16
ELOC elongin C SLC25A3 solute carrier family 25 member 3
EMCN endomucin SLC25A5 solute carrier family 25 member 5
EMILIN1 elastin microfibril interfacer 1 SLC29A1 solute carrier family 29 member 1 (Augustine blood group)
ENDOD1 endonuclease domain containing 1 SLC2A1 solute carrier family 2 member 1
ENO1 enolase 1 SLC3A2 solute carrier family 3 member 2
ENO2 enolase 2 SLC40A1 solute carrier family 40 member 1
ENPEP glutamyl aminopeptidase SLC43A1 solute carrier family 43 member 1
Symbol Entrez Gene Name Symbol Entrez Gene Name
EPB41 erythrocyte membrane protein band 4.1 SLC43A3 solute carrier family 43 member 3
ERBIN erbb2 interacting protein SLC44A2 solute carrier family 44 member 2
ESD esterase D SLC4A1 solute carrier family 4 member 1 (Diego blood group)
EZR ezrin SLC7A1 solute carrier family 7 member 1
F2R coagulation factor II thrombin receptor SLC7A5 solute carrier family 7 member 5
FABP4 fatty acid binding protein 4 SLC9A3R1 SLC9A3 regulator 1
FABP5 fatty acid binding protein 5 SLC9A3R2 SLC9A3 regulator 2
FAM151A family with sequence similarity 151 member A SNTB1 syntrophin beta 1
FAM234B family with sequence similarity 234 member B SNX12 sorting nexin 12
FAS Fas cell surface death receptor SNX3 sorting nexin 3
FBN1 fibrillin 1 SOD1 superoxide dismutase 1
FCGR2A Fc gamma receptor IIa SOD2 superoxide dismutase 2
FCGRT Fc gamma receptor and transporter SRGN serglycin
FDPS farnesyl diphosphate synthase ST13 ST13 Hsp70 interacting protein
FHL1 four and a half LIM domains 1 STAM signal transducing adaptor molecule
FIS1 fission, mitochondrial 1 STAM2 signal transducing adaptor molecule 2
FKBP1A FKBP prolyl isomerase 1A STAT5A signal transducer and activator of transcription 5A
FLII FLII actin remodeling protein STEAP3 STEAP3 metalloreductase
FLOT2 flotillin 2 STIM1 stromal interaction molecule 1
FYB1 FYN binding protein 1 STIP1 stress induced phosphoprotein 1
GABARAPL2 GABA type A receptor associated protein like 2 STK10 serine/threonine kinase 10
GAPDH glyceraldehyde‐3‐phosphate dehydrogenase STK24 serine/threonine kinase 24
GCA grancalcin STK26 serine/threonine kinase 26
GDI1 GDP dissociation inhibitor 1 STX12 syntaxin 12
GDI2 GDP dissociation inhibitor 2 STX16 syntaxin 16
GGT1 gamma‐glutamyltransferase 1 STX4 syntaxin 4
GLIPR2 GLI pathogenesis related 2 STX6 syntaxin 6
GMPR guanosine monophosphate reductase STX8 syntaxin 8
GNA13 G protein subunit alpha 13 SUSD3 sushi domain containing 3
GNAI1 G protein subunit alpha i1 SYNGR2 synaptogyrin 2
GNAI2 G protein subunit alpha i2 SYTL4 synaptotagmin like 4
GNAI3 G protein subunit alpha i3 TALDO1 transaldolase 1
GNB1 G protein subunit beta 1 TBXAS1 thromboxane A synthase 1
GNG10 G protein subunit gamma 10 TCP1 t‐complex 1
GNG11 G protein subunit gamma 11 TESC tescalcin
GNG2 G protein subunit gamma 2 TFRC transferrin receptor
GNG5 G protein subunit gamma 5 TGFBRAP1 transforming growth factor beta receptor associated protein 1
GNG7 G protein subunit gamma 7 TKT transketolase
GOLGA7 golgin A7 TM4SF4 transmembrane 4 L six family member 4
GPI glucose‐6‐phosphate isomerase TM9SF2 transmembrane 9 superfamily member 2
GPRC5C G protein‐coupled receptor class C group 5 member C TMEM9B TMEM9 domain family member B
GPX1 glutathione peroxidase 1 TNIK TRAF2 and NCK interacting kinase
GPX4 glutathione peroxidase 4 TPM3 tropomyosin 3
GRK6 G protein‐coupled receptor kinase 6 TPM4 tropomyosin 4
GSR glutathione‐disulfide reductase TRBC1 T cell receptor beta constant 1
GSTM5 glutathione S‐transferase mu 5 TRPC6 transient receptor potential cation channel subfamily C member 6
GSTO1 glutathione S‐transferase omega 1 TSG101 tumor susceptibility 101
GSTP1 glutathione S‐transferase pi 1 TSPAN14 tetraspanin 14
GTPBP2 GTP binding protein 2 TSPAN32 tetraspanin 32
GYPC glycophorin C (Gerbich blood group) TSPAN4 tetraspanin 4
HBA1/HBA2 hemoglobin subunit alpha 2 TWF2 twinfilin actin binding protein 2
HBB hemoglobin subunit beta TXN thioredoxin
HBD hemoglobin subunit delta TXNL1 thioredoxin like 1
HEBP2 heme binding protein 2 UBA7 ubiquitin like modifier activating enzyme 7
HPRT1 hypoxanthine phosphoribosyltransferase 1 UBASH3B ubiquitin associated and SH3 domain containing B
HPSE heparanase UBC ubiquitin C
HSD17B4 hydroxysteroid 17‐beta dehydrogenase 4 UBE2L3 ubiquitin conjugating enzyme E2 L3
HSP90AB1 heat shock protein 90 alpha family class B member 1 UBE2V1 ubiquitin conjugating enzyme E2 V1
HSP90B1 heat shock protein 90 beta family member 1 UMAD1 UBAP1‐MVB12‐associated (UMA) domain containing 1
HSPA2 heat shock protein family A (Hsp70) member 2 USP8 ubiquitin specific peptidase 8
HSPA4 heat shock protein family A (Hsp70) member 4 VAMP3 vesicle associated membrane protein 3
HSPA6 heat shock protein family A (Hsp70) member 6 VAMP5 vesicle associated membrane protein 5
HSPA8 heat shock protein family A (Hsp70) member 8 VAMP7 vesicle associated membrane protein 7
HSPD1 heat shock protein family D (Hsp60) member 1 VAMP8 vesicle associated membrane protein 8
HSPE1 heat shock protein family E (Hsp10) member 1 VNN1 vanin 1
ICAM1 intercellular adhesion molecule 1 VPS11 VPS11 core subunit of CORVET and HOPS complexes
ICAM3 intercellular adhesion molecule 3 VPS28 VPS28 subunit of ESCRT‐I
IDH1 isocitrate dehydrogenase (NADP(+)) 1 VPS35 VPS35 retromer complex component
IGSF8 immunoglobulin superfamily member 8 VPS37B VPS37B subunit of ESCRT‐I
IPO5 importin 5 VPS4A vacuolar protein sorting 4 homolog A
IQGAP1 IQ motif containing GTPase activating protein 1 VPS4B vacuolar protein sorting 4 homolog B
IQGAP2 IQ motif containing GTPase activating protein 2 VPS8 VPS8 subunit of CORVET complex
IST1 IST1 factor associated with ESCRT‐III VTA1 vesicle trafficking 1
ITGA4 integrin subunit alpha 4 VTI1B vesicle transport through interaction with t‐SNAREs 1B
ITGA6 integrin subunit alpha 6 WARS1 tryptophanyl‐tRNA synthetase 1
ITGAL integrin subunit alpha L WASF2 WASP family member 2
ITGAM integrin subunit alpha M WASF3 WASP family member 3
ITGB1 integrin subunit beta 1 WBP2 WW domain binding protein 2
ITGB2 integrin subunit beta 2 WDSUB1 WD repeat, sterile alpha motif and U‐box domain containing 1
KALRN kalirin RhoGEF kinase XPO1 exportin 1
KATNAL2 katanin catalytic subunit A1 like 2 YKT6 YKT6 v‐SNARE homolog
KEL Kell metallo‐endopeptidase (Kell blood group) YWHAE tyrosine 3‐monooxygenase/tryptophan 5‐monooxygenase activation protein epsilon
KIF2A kinesin family member 2A ZDHHC2 zinc finger DHHC‐type palmitoyltransferase 2