TABLE 4.

Correlation between amino acid sequence and activity

Peptide	Sequenceb	Effecta on gp120 binding to:
		CD4	MAb 17b
12p1	R I N N I P W S E A M M	−−−−−	−−−−−
12p3	D T H R W P W Y I S Q E	−	−−
7p1	S W P W D T W	−−	−−
7p2	F W H P M H D	−−	−−
12p2	T S P Y E D W Q T Y L M	0	+++++
12p5	S P W Y S D Y T R Y L W	0	+++
12p6	S D P Y K L W A S Y M Y	0	+++++
C7Cp1	C H P L T P W E C	0	+++

^aMinus signs indicate inhibition; plus signs indicate enhancement; 0 indicates no effect. 

^bUnderlined amino acids represent the core sequence as identified from alanine-scanning and truncation experiments (see the text).