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. 2024 Jul 8;128(28):11699–11708. doi: 10.1021/acs.jpcc.4c02229

Figure 1.

Figure 1

Illustration of DNA-directed assembly strategies. (a) Direct linkage: where DNA linkers’ flexibility introduces variability in overall shape and gap size differences. (b) Traditional template-driven self-assembly, where polydispersity in NP sizes leads to gap size variability. (c) D-DOC: a central gold NP (AuNP) is enclosed within a 3D DNA origami cage via base pairing with thiolated DNA ligands and ICS (blue helices). Terminal AuNPs are captured by OCS (red helices) at the cage’s openings, forming a linear heterotrimer. (d) Cross-sectional views show diametrically arranged multiple capture strands confining each NP stabilized by shape complementarity with the cage. Gap size is controlled by the thickness of the ligand shells, minimizing the effect of NP polydispersity.