Table 3.
B (95% CI) | SE | p-value | |
---|---|---|---|
Model 1a | |||
Global Aβ deposition | 0.477 (0.314–0.640) | 0.082 | 0.000 |
Model 2b | |||
Global Aβ deposition x T3 | 0.002 (-0.008–0.011) | 0.005 | 0.707 |
Global Aβ deposition x TSH | -0.072 (-0.153–0.008) | 0.040 | 0.078 |
Global Aβ deposition x fT4 | 1.022 (0.375–1.668) | 0.324 | 0.002 |
Global Aβ deposition x fT3 | 0.714 (0.307–1.121) | 0.204 | 0.001 |
Notes: a A multiple linear regression model for IT tau deposition included Global Aβ deposition as an independent variable, after adjusting for age, sex, and APOE ε4 positivity
b Multiple linear regression models for IT tau deposition included serum thyroid hormones and global Aβ as interactive predictors, after adjusting for age, sex, and APOE ε4 positivity
Summary of the model: IT tau ~ Global Aβ deposition x Thyroid hormone + Thyroid hormone + Global Aβ deposition + age + sex + APOE ε4 positivity
Abbreviations: Aβ beta-amyloid, T3 triiodothyronine, T4 thyroxine, TSH thyroid-stimulating hormone, IT inferior temporal, APOE Apolipoprotein E, CI confidence interval, SE standard error