Table 3.

Interaction effects of thyroid hormones with Aβ deposition on tau deposition (n = 74)

	B (95% CI)	SE	p-value
Model 1a
Global Aβ deposition	0.477 (0.314–0.640)	0.082	0.000
Model 2b
Global Aβ deposition x T3	0.002 (-0.008–0.011)	0.005	0.707
Global Aβ deposition x TSH	-0.072 (-0.153–0.008)	0.040	0.078
Global Aβ deposition x fT4	1.022 (0.375–1.668)	0.324	0.002
Global Aβ deposition x fT3	0.714 (0.307–1.121)	0.204	0.001

Notes: ^a A multiple linear regression model for IT tau deposition included Global Aβ deposition as an independent variable, after adjusting for age, sex, and APOE ε4 positivity

^b Multiple linear regression models for IT tau deposition included serum thyroid hormones and global Aβ as interactive predictors, after adjusting for age, sex, and APOE ε4 positivity

Summary of the model: IT tau ~ Global Aβ deposition x Thyroid hormone + Thyroid hormone + Global Aβ deposition + age + sex + APOE ε4 positivity

Abbreviations: Aβ beta-amyloid, T3 triiodothyronine, T4 thyroxine, TSH thyroid-stimulating hormone, IT inferior temporal, APOE Apolipoprotein E, CI confidence interval, SE standard error