Skip to main content
. 2024 Jul 23;25:502. doi: 10.1186/s13063-024-08280-w
Title {1} Influence of Cooling duration on Efficacy in Cardiac Arrest Patients (ICECAP): study protocol for a multicenter, randomized, adaptive allocation clinical trial to identify the optimal duration of induced hypothermia for neuroprotection in comatose, adult survivors of after out-of-hospital cardiac arrest
Trial registration {2a and 2b} ClinicalTrials.gov: NCT04217551
Protocol version {3} Version 1, April 14th, 2020
Funding {4}

Supported by grants:

UG3HL145269,UH3HL145269,U24HL145272,U24NS100659, U24NS100655 from

The National Heart, Lung and Blood Institute (NHLBI) and the National Institute Of Neurological Disorders and Stroke (NINDS)

This work was supported jointly by the National Institutes of Health Common Fund (Office of the Director) and the Food and Drug Administration, with funding administered by NINDS U01NS073476

Author details {5a}

CORRESPONDING AUTHOR

William J Meurer, MD, MS, wmeurer@med.umich.edu, University of Michigan, Emergency Medicine, Neurology, Ann Arbor, MI

TC B1-354

1500 E. Medical Center Drive

48109–5301

Florian F Schmitzberger, MD, MS, fschmitz@med.umich.edu, University of Michigan, Emergency Medicine, Ann Arbor, MI

Sharon Yeatts, PhD, yeatts@musc.edu, Medical University of South Carolina, Public Health Sciences, Charleston, SC

Viswanathan Ramakrishnan, Phd, Ramakris@musc.edu, Medical university of South Carolina, Public health sciences, Charleston, SC

Benjamin Abella, MD MPhil, benjamin.abella@pennmedicine.upenn.edu, University of Pennsylvania, Emergency Medicine, Philadelphia, PA

Tom Aufderheide, MD, MS, taufderh@mcw.edu, Medical College of Wisconsin, Emergency Medicine, Milwaukee, WI

William Barsan, MD, Wbarsan@umich.edu, University of Michigan, Emergency Medicine, Ann Arbor, MI

Justin Benoit, MD, MS, justin.benoit@uc.edu, University of Cincinnati, Emergency Medicine, Cincinnati, OH

Scott Berry, PhD, scott@berryconsultants.net, Berry Consultants,, TX

Joy Black, BSN, MS, joypink@med.umich.edu, University of Michigan, ThermoFisher Scientific, Emergency Medicine, Neuroscience, Ann Arbor, MI

Nia Bozeman, BA, nbozeman@med.umich.edu, University of Michigan, Emergency Medicine, Ann Arbor, MI

Kristine Broglio, M.S., KRBroglio@gmail.com, Berry Consultants, Oncology Statistical Innovation, Gaithersburg MD

Jeremy Brown, MD, jeremy.brown@nih.gov, National Institutes of Health, National Institute of Neurological Disorders and Stroke, Bethesda, MD

Kimberly Brown, MBA, brokimbe@med.umich.edu, University of Michigan, Emergency Medicine, Ann Arbor, MI

Noelle Carlozzi, PhD, carlozzi@med.umich.edu, University of Michigan, Physical Medicine and Rehabilitation, Surgery, Ann Arbor, MI

Angela Caveney, PhD, angif@umich.edu, University of Michigan, Emergency Medicine, Ann Arbor, MI

Sung-Min Cho, DO, MHS, csungmi1@jhmi.edu, Johns Hopkins Hospital, Anesthesia, Critical Care Medicine, Baltimore, MD

Hangyul Chung-Esaki, MD, hesaki@queens.org, The Queen’s Medical Center, University of Hawaii John A. Burns School of Medicine, Critical Care, Honolulu, HI

Robert Clevenger, MPH, clevenge@musc.edu, Medical University of South Carolina, Public Health Sciences, Charleston, SC

Robin Conwit, MD, Rconwit@iu.edu, Indiana University, Neurology, Indianapolis, IN

Richelle Cooper, MD, MSHS, RCooper@mednet.ucla.edu, UCLA David Geffen School of Medicine, Emergency Medicine, Los Angeles, CA

Valentina Crudo, MD, vcrudo@med.umich.edu, University of Michigan, Emergency Medicine, Ann Arbor, MI

Mohamud Daya, MD, MSc, dayam@ohsu.edu, Oregon Health & Science University, Emergency Medicine, Portland, OR

Deneil Harney, MPH, MSW, dkolk@umich.edu, University of Michigan, Emergency Medicine, Ann Arbor, MI

Cindy Hsu, MD, PhD, hcindy@med.umich.edu, University of Michigan, Emergency Medicine, Ann Arbor, MI

Nicholas J Johnson, MD, nickj45@uw.edu, University of Washington, Emergency Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Medicine, Seattle, WA

Imad Khan, MD, imad_khan@urmc.rochester.edu, University of Rochester Medical Center, Neurology, Rochester, NY

Shaveta Khosla, PhD MPH, skhosl2@uic.edu, University of Illinois Chicago, Emergency Medicine, Chicago, IL

Peyton Kline, MHA, BSPH, CCRP, peyton@musc.edu, Medical University of South Carolina, Public Health Sciences, Charleston, SC

Anna Kratz, PhD, alkratz@med.umich.edu, University of Michigan, Physical Medicine and Rehabilitation, Ann Arbor, MI

Peter Kudenchuk, MD, pkudenchuk@cardiology.washington.edu, University of Washington, Medicine, Division of Cardiology, Seattle, WA

Roger J Lewis, MD, PhD, roger@berryconsultants.net, David Geffen School of Medicine at UCLA, Emergency Medicine, Los Angeles, CA

Chaitra Madiyal, M.S., cmadiyal@gmail.com, University of Michigan, Emergency Medicine, Ann Arbor, MI

Sara Meyer, BS, butlers@musc.edu, Medical University of South Carolina, Public Health and Sciences, Charleston, SC

Jarrod Mosier, MD, jmosier@arizona.edu, University of Arizona, Emergency Medicine, Medicine, Tucson, AZ

Marwan Mouammar, MD, Mmouammar@gmail.com, OHSU Portland Adventist Medical Center, Medicine, Critical Care Medicine, Portland, OR

Matthew Neth, MD, neth@ohsu.edu, Oregon Health & Science University, Emergency Medicine, Portland, OR

Brian O'Neil, MD, boneil@med.wayne.edu, Wayne State University, Emergency Medicine, Detroit, MI

James Paxton, MD MBA, jpaxton@med.wayne.edu, Wayne State University, Emergency Medicine, Detroit, Michigan

Sofia Perez, BS, persof@umich.edu, University of Michigan, Emergency Medicine Research, Ann Arbor, MI

Sarah Perman, MD, MSCE, Sarah.perman@yale.edu, Yale School of Medicine, Emergency Medicine, New Have CT

Cemal Sozener, MD, MEng, cemal@med.umich.edu, University of Michigan, Emergency Medicine, Ann Arbor, MI

Mickie Speers, BSN, LRAES@med.umich.edu, University of Michigan, Emergency Medicine, Ann Arbor, MI

Aimee Spiteri, AAS, abspiter@med.umich.edu, University of Michigan, Emergency Medicine, Ann Arbor, MI

Valerie Stevenson, BAS, vwillis@umich.edu, University of Michigan, Emergency Medicine, Ann Arbor, MI

Kavita Sunthankar, BSN, MSN, patelka90@gmail.com, Medical University of South Carolina, Data Coordination Unit, Charleston, SC

Joseph Tonna, MD, MS, joseph.tonna@hsc.utah.edu, University of Utah Health, Surgery, Salt Lake City, UT

Scott Youngquist, MD, MS, scott.youngquist@utah.edu, Spencer Eccles School of Medicine at the University of Utah, Emergency Medicine, Salt Lake City, UT

Romergryko Geocadin, MD, rgeocad1@jhmi.edu, Johns Hopkins University School of Medicine, Neurology, Anesthesiology-Critical Care Medicine, Neurosurgery, Baltimore, MD

Robert Silbergleit, MD, robie@med.umich.edu, University of Michigan, Emergency Medicine, Ann Arbor, MI

For the ICECAP trial investigators (names in acknowledgments section)

Name and contact information for the trial sponsor {5b}

National Institute of Health: National Heart, Lung, and Blood Institute (NIH NHLBI): National Heart, Lung, and Blood Institute, Building 31, 31 Center Drive, Bethesda, MD 20892

National Institute of Health: National Institute of Neurological Disorders and Stroke (NIH NINDS): NIH Neurological Institute, P.O. Box 5801; Bethesda, MD 20824

Role of sponsor {5c} The study sponsors do not have any role in any trial design decisions