Table 1. Cocaine-based experiments .
| Addictive drug | Manipulation | Target | Subjects | Main findings/References |
| Cocaine | Suvorexant | dual OX1/2R | R (rat) | Attenuation of cocaine-induced impulsive behaviors (systematic or direct injection in VTA)67 |
| Suvorexant | dual OX1/2R | R | Attenuation of the hedonic and motivational effect induced by cocaine56 | |
| SB-334867 | OX1R | R | Counteracts the development of cocaine self-administration and attenuates the induction of amphetamine-induced CPP54 | |
| SB-334867 | OX1R | R | Administration of SB-334867 decreased cocaine intake (in a dose-dependent manner)48 | |
| SB-334867 | OX1R | M (mice) | SB-334867 blocks CPP induced by micro-injection of orexin in VTA 65 | |
| SB-334867 | OX1R | M | SB-334867 injections (in VTA) attenuated impulsive-like behavior, LH self-stimulation, and cocaine self-administration57 | |
| SB-334867 | OX1R | R | Diminished the motivation for cocaine50 | |
| SB-334867 | OX1R | Female monkeys (rhesus) |
Reduced cocaine self-administration58 | |
| SB-334867 | OX1R | R | Decreased demand for cocaine (in the presence of cocaine-related cues)66 | |
| SB-334867 | OX1R | R | Blocking OX1R or OX1R and OX2R together reduces the effect of cocaine on dopamine signaling and cocaine motivation, but blocking OX2R alone showed no effect55 | |
| Almorexant | dual OX1/2R | R | Decrease cocaine self-administration and weaken cocaine-induced dopamine uptake inhibition55 | |
| RTIOX-276 | OX1R | R | Attenuation of cocaine-induced inhibition of dopamine uptake68 |