. 2024 May 1;16(2):130–139. doi: 10.34172/ahj.2024.1491

Table 2. Amphetamine/cannabis/nicotine-based experiments .

Addictive drug	Manipulation	Target	Subjects	Main findings/ References
Amphetamine	Almorexant	dual OX1/2R	R (rat)	Decreased cocaine and amphetamine-induced CPP expression but did not affect morphine-induced CPP expression/Interfered with morphine-induced locomotor sensitization but had no effect on cocaine and amphetamine-induced locomotor sensitization⁶³
	SB-334867	OX1R	R	Decreased amphetamine-induced dopamine outflow (in NAc) and reduced amphetamine-induced sensitization⁶⁴
Cannabis	SB-334867	OX1R	M (mice)	SB-334867 reduced the reinforcing and motivational properties of WIN55,212-2 (SORA2-TCS-OX2-29 had no effect)⁶⁹
Nicotine	TCS 1102	dual OX1/2R	R	It had no effect on nicotine-seeking behavior⁷⁰
	SB-334867	OX1R	M	Administration of SB-334867 reduced the somatic signs of nicotine-induced withdrawal but SORA2-TCS-OX2-29 had no effect⁷¹