FIG. 7.

Inhibition of HIV-1 replication in AM by chemokines. AM were infected with primary HIV-1 isolates in the presence of 250 ng of RANTES, MIP-1α, MIP-1β, or SDF-1/ml or all chemokines together. HIV-1 p24 antigen was measured in the culture supernatants on day 10 after virus inoculation. The percent inhibition was calculated based on control cultures infected without added chemokines. Data are means of duplicate wells from one (of three) representative experiment. Shown are results for isolates AD2-2 (coreceptor used, CCR5), AD2-6 (coreceptors used, CCR5 and CXCR4), AD3-3 (coreceptor used, CCR5), AD3-7 (coreceptors used, CCR5, CXCR4, CCR2b, and CCR3), and JRFL (coreceptor used, CCR5).