Table 2.

MYDGF in diseases associated with metabolic disorders

Disease	Model	Effect	Pathway	Reference
Diabetes	MYDGF-/- mice	Maintain glucose homeostasis by inducing GLP-1 production and secretion and improve glucose tolerance and lipid metabolism	PKA/GSK-3β/β-catenin, MAPK/MEK/ERK	(Wang et al. 2020a, b)
Non-alcoholic fatty liver disease	Myeloid cell-specific MYDGF knockout mice	Alleviate hepatic inflammation, lipogenesis, and steatosis	PKC/IKKβ/NF-κB	(Ding et al. 2023)
Osteoporosis	Myeloide cell-specific MYDGF knockout mice	Inhibit osteoclastogenesis and promote osteoblast differentiation	PKCβ/NF-κB, MAPK1/3-STAT3	(Xu et al. 2022)