Fig. 2.

Circ_0007386 promotes the proliferation and inhibits apoptosis of NSCLC cells in vitro. A. The expression levels of circ_0007386 and CRIM1 mRNA were assessed in A549 and H1299 cells after transfection with circ_0007386 siRNA and overexpression vector (si-circ_0007386 and circ_0007386) alongside the controls (si-NC and vector). B-D. CCK8 and colony formation assays were performed to determine cell proliferation in the indicated cell lines. E-H. TUNEL staining assay and flow cytometry were used to evaluate the effect on apoptosis in A549 and H1299 cells after circ_0007386 knockdown or overexpression treatment. Images are shown at 400× magnification. Scale bar = 40 μm. Data are shown as the means ± SD. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001