Fig. 3.

Circ_0007386 affects tumorigenesis of NSCLC cells in vivo. (A) Representative images of subcutaneous tumor nude mouse model, showing hypodermic injection of cells stably transfected with lentivirus expressing circ_0007386 knockdown (sh-circ_007386) or overexpression construct (pLCDH-circ_0007386) and their controls (sh-NC and pLCDH-vector) to establish subcutaneous xenograft tumors. (B) Images of subcutaneous xenograft tumors (n = 5 per group). (C) Tumor weight was assessed for each group. (D) Tumor volume was measured every week. E-F. HE, Ki67, Bcl2, and BAX IHC staining of xenograft tumors, with images shown at 400× magnification. Scale bar = 50 μm. Data are shown as the means ± SD. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001