Table 5.

Studies assessing OTC products for combinations of conditions

Study Details	Product used	Comparator used	Measure(s) used	Effective?	Side effects
Etedali et al., 2022 [47] Iran N = 63 Comorbidity-prostate cancer	Melatonin 3 mg twice a day 4 weeks	No treatment	PSQI HAM-A BDI	Yes (for insomnia, not depression or anxiety)	Excessive daytime sleepiness with melatonin
Yu et al., 2019 [68] China N = 90 Comorbidity- Obstructive sleep apnoea	1. Rhodiola rosea L. 0.6 g twice a day 2. Rhodiola rosea L. + CPAP machine 3 months	CPAP machine only	SDS SAS	Yes for depression and anxiety when used with CPAP but not alone	Not reported

BDI Beck Depression Inventory, HAM-A Hamilton Anxiety Rating Scale, PSQI Pittsburgh Sleep Quality Index, SAS Self-rating Anxiety Scale, SDS Self-rating Depression Scale