Table 5.
Mean live Amblyomma americanum counts following a day 28 challenge of dogs left untreated or treated on day 0 with sarolaner, afoxolaner or lotilaner (8 dogs per group)
| Hours post-challenge | 4 | 8 | 12 | 24 | 48 | 72 | |
|---|---|---|---|---|---|---|---|
| Untreated | Geometric mean (SE) | 29.3 (0.1) | 28.6 (0.1) | 26.9 (0.1) | 26.9 (0.1) | 29.7 (0.3) | 29.2 (0.3) |
| Arithmetic mean (SE) | 29.6 (1.9) | 28.8 (1.9) | 27.4 (2.5) | 27.9 (2.0) | 30.5 (2.9) | 30.3 (2.4) | |
| Median | 30.0 | 29.5 | 26.5 | 28.0 | 29.0 | 29.0 | |
| Range | 21–35 | 22–32 | 19–38 | 16–41 | 20–40 | 19–50 | |
|
Sarolaner (Simparica Trio) |
Geometric mean (SE) | 24.7 (0.1) | 22.3 (0.1) | 22.3 (0.1) | 25.6 (0.1) | 9.1 (0.3) | 0.8 (0.3) |
| Arithmetic mean (SE) | 25.3 (1.9) | 22.9 (1.9) | 23.4 (2.5) | 26.4 (2.0) | 12.3 (2.9) | 1.1 (2.4) | |
| Median | 24.0 | 22.5 | 20.5 | 25.5 | 9.5 | 1.0 | |
| Range | 18–33 | 16–31 | 15–35 | 16–38 | 2–26 | 0–5 | |
|
Afoxolaner (NexGard) |
Geometric mean (SE) | 27.1 (0.1) | 25.9 (0.1) | 24.4 (0.1) | 27.1 (0.1) | 14.0 (0.3) | 4.0 (0.3) |
| Arithmetic mean (SE) | 27.4 (1.9) | 26.8 (1.9) | 24.8 (2.5) | 27.3 (2.0) | 19.4 (2.9) | 7.6 (2.4) | |
| Median | 26.5 | 26.5 | 24.0 | 27.5 | 20.0 | 3.0 | |
| Range | 23–36 | 17–37 | 20–33 | 24–32 | 0–34 | 0–26 | |
|
Lotilaner (Credelio) |
Geometric mean (SE) | 27.8 (0.1) | 21.3 (0.1) | 14.0 (0.1) | 2.1 (0.1) | 0.3 (0.3) | 0.5 (0.3) |
| Arithmetic mean (SE) | 28.4 (1.9) | 21.8 (1.9) | 16.4 (2.5) | 2.8 (2.0) | 0.5 (2.9) | 1.0 (2.4) | |
| Median | 27.0 | 21.5 | 15.5 | 2.5 | 0.0 | 0.0 | |
| Range | 22–38 | 14–32 | 5–29 | 0–9 | 0–3 | 0–6 |
Sarolaner product combined with moxidectin and pyrantel
Infestations with 50 A. americanum per dog
SE, standard error