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. 2024 Jul 20;16:96. doi: 10.1186/s13148-024-01710-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — LV-mediated SIRT6 mutant overexpression and its impact on insulin sensitivity in 3T3-L1 cells. A immunoblotting to assess pAKT^Ser473 and SIRT6 protein expression levels, in cells infected with LV-SIRT6 (WT or N308K/A318S) or empty control. B Densitometric quantification as in (B). (C) 3T3-L1 cells infected with LV-SIRT6 (WT or N308K/A318S) or empty control were treated with/without 50 nM NPY for 12 h and/or 100 nM insulin (INS) for 30 min to detect basal glucose uptake. ***p < 0.001, ****p < 0.0001 (Mann–Whitney U test)