TABLE 2.
HI reactivity of serum samples from vaccinated mice for influenza A H5 viruses
| Serum | HI antibody titer
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| dk/Sing (H5N3) | H5N1 group A
|
H5N1 group B
|
|||||||
| HK/156 | HK/486 | HK/516 | HK/538 | HK/483 | HK/485 | HK/491 | HK/514 | ||
| Vaccinated micea | |||||||||
| dk/Sing | 80 | 80 | 40 | 40 | 40 | 40 | 40 | 80 | 40 |
| dk/Sing + alum | 320 | 320 | 160 | 320 | 640 | 160 | 80 | 320 | 160 |
| Alum | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 |
| Infected ferretsb | |||||||||
| dk/Sing | 160 | 160 | 80 | 160 | 160 | 40 | 40 | 80 | 80 |
| HK/156 | 160 | 160 | 160 | 160 | 160 | 20 | 20 | 80 | 80 |
| HK/483 | 160 | 160 | 80 | 160 | 160 | 160 | 40 | 80 | 80 |
a
Serum samples from groups of 17 to 22 mice immunized with dk/Sing vaccine with or without alum or alum alone were collected 3 weeks after the second vaccination and were pooled for HI assay against H5N1 group A and group B viruses.
b
Serum samples from single ferrets infected with dk/Sing, HK/483, or HK/156 virus were concentrated fourfold. The ferret infected with HK/156 virus was also inoculated i.n. with A/Turkey/Wisconsin/68 virus (H5N9).