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. 2024 Jul 22;24:250. doi: 10.1186/s12883-024-03761-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Brain autopsy findings in patient 1. Thickening of periventricular areas that are infiltrated by a diffuse population of large tumor cells without glandular or squamous differentiation (A, Hematoxylin–Eosin staining). The tumor is composed of a diffuse proliferation of large cells with a high nucleo-cytoplasmic ratio, mono- and multilobated nuclei, numerous mitoses (B, Giemsa staining) and high proliferation index Ki67/MIB1 near 80% (G). Tumor cells express CD20 (C), with coexpression of Bcl2 (D), Bcl6 (E) and MUM1 (F), and are monotypic for immunoglobulin light chain lambda, consistent with the diagnosis of primary diffuse large B-cell lymphoma of CNS (EBV negative, not shown)