Fig. 8.

Top 20% genes and CpG sites that approximate the original data are used to obtain shared low-dimensional representations, and reconstructed gene expression and methylation data. A Kaplan–Meier plots comparing survival curves for clusters obtained from the shared low-dimensional representations, and the reconstructed data. Survival curves for the clusters based on the joint and low-dimensional representations and reconstructed methylation data are significantly different. B–D Clusters are derived from the shared low-dimensional representation. B Comparison of 10-year survival rates across clusters. Chi-square test of independence shows that the clusters detected are significantly associated with 10-year survival event (p-value = 0.011). C Violin plot of overall survival time by clusters. The average survival times are significantly different across clusters. D Comparison of hazard ratios and survival curves across clusters