Table 10.
Genes selected. Top 10 Pathways enriched with ToppFun in ToppGene Suite
| ID | Pathway | Source | Bonferroni P-value |
Genes |
|---|---|---|---|---|
| 1270244 | Extracellular matrix organization | BioSystems: REACTOME | 5.117E-08 |
COL6A1,MFAP4,SPARC,MMP2 DCN,TIMP2,LOX,VCAN,BGN,COL1A2 |
| M5889 | Ensemble of genes encoding extracellular matrix | MSigDB C2 BIOCARTA | 0.000000478 | SLIT2,COL6A1,MFAP4,THBS2 |
| and extracellular matrix-associated proteins |
IL16,SPARC,MMP2,DCN,IGFBP7 ITIMP2,LOX,VCAN,BGN,COL1A2 |
|||
| 1269016 | Defective CHSY1 causes TPBS | BioSystems: REACTOME | 0.0001055 | DCN,VCAN,BGN |
| 1269017 | Defective CHST3 causes SEDCJD | BioSystems: REACTOME | 0.0001055 | DCN,VCAN,BGN |
| 1269018 |
Defective CHST14 causes EDS, musculocontractural type |
BioSystems: REACTOME | 0.0001055 | DCN,VCAN,BGN |
| 1269986 | Dermatan sulfate biosynthesis | BioSystems: REACTOME | 0.0004947 | DCN,VCAN,BGN |
| 1269987 | CS/DS degradation | BioSystems: REACTOME | 0.001087 | DCN,VCAN,BGN |
| 1270256 | ECM proteoglycans | BioSystems: REACTOME | 0.001966 | SPARC,DCN,VCAN,BGN |
| 1309217 | Defective B3GALT6 causes EDSP2 and SEMDJL1 | BioSystems: REACTOME | 0.002875 | DCN,VCAN,BGN |