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. 2024 Jul 22;22:432. doi: 10.1186/s12951-024-02722-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — therapeutic efficacy and histopathological analysis. (a) schematic of acupuncture and experimental workflow. (b) images of lower limbs across different groups. (c) arthritic scores of mice in each group. (d) comparison of hind paw thickness in each group. (e) comparison of ankle joint thickness in each group. (f) cartilage staining (he, masson, so-fg, t&b) in various groups. green arrows: invasion of inflammation. red arrows: formation of pannus. black triangle: loss of proteoglycan. scale bars: 100 μm. (g) synovial histopathology (he) and immunohistochemistry images in different groups. green arrows: invasion of inflammation. black arrows: positive staining. scale bars: 100 μm