FIG. 3.
Survival of LCMV infection is increased in perforin-deficient mice expressing LCMV NP in their thymuses. Groups of 20 mice were infected with 105 PFU of LCMV intraperitoneally and maintained under specific-pathogen-free conditions in viral containment for the duration of the study. Statistically significant differences (survival log-rank test used for calculation of P value; P < 0.05 was considered significant) were found between the groups p−/− NP−, p−/− NP+, and p+/+ (H-2b). p+/− NP+ or p+/− NP− mice survived infection similar to the p+/+ controls shown.