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. Author manuscript; available in PMC: 2024 Jul 23.
Published in final edited form as: Environ Toxicol Chem. 2023 Jan 16;42(2):463–474. doi: 10.1002/etc.5537

Figure 3.

Figure 3.

Superposed structures of the full human androgen receptor (AR) model generated using I-TASSER (green) with the full protein model for A. dog (Canis lupus familiaris) canine androgen receptor (NCBI Accession BCD56309.1; orange), B. chicken (Gallus gallus) androgen receptor (NCBI Accession NP_001035179.1; purple), C. African clawed frog (Xenopus laevis) androgen receptor alpha isoform (NCBI Accession AAC97386.1; magenta). The Average TM-align Score calculated by taking the average of the TM-align Score normalized to the dog, chicken, African clawed frog AR model and the TM-align Score normalized to the Human 2AMA, between the pairwise comparisons (Supplemental Data, S4). TM-align score is a metric for assessing the topological similarity of protein structures and has a value between 0 and 1, where 1 indicates a perfect match between two structures. Illustrations made using Molecular Operating Environment (MOE) software (Chemical Computing Group, Montreal, QC, Canada).