Fig 4.

Lesion characteristics in Ever2-null and wild-type mice infected with 10⁹ VGE MmuPV1 without irradiation. Ear and tail sites were wounded to induce scarification and topically treated with MmuPV1 virions. Onset of overt lesions was monitored, and lesions were measured every other week over a period of 22 weeks postinfection. (A) Onset of lesions did not differ between Ever2-null and wild-type mice (P = 0.13, log-rank test, n = 15–18 infected sites per genotype). (B) Lesions grew more slowly in Ever2-null mice than in wild-type mice (P = 0.018, type 3 test of interaction effect of Genotype × Week² in a quadratic mixed model, n = 13 lesions per genotype). (C) Maximum lesion volume did not differ between Ever2-null and wild-type mice (P = 0.69, Wilcoxon rank-sum test, n = 13 lesions per genotype). (D) Lesion regression was higher in Ever2-null mice than in wild-type mice (P = 0.021, Wilcoxon rank-sum test, n = 13 lesions per genotype). (E) Disease severity did not differ between Ever2-null and wild-type mice (P = 0.57, Wilcoxon rank-sum test, n = 5–9 infected sites scored per genotype).