Fig 2.

(A) Upon provocative motion, humans and mice will show a decrease in head temperature, which recovers once rotation is ceased, and mice show a transient tail spike ~10 minutes into rotation. Heat image examples similar to (25). When nausea or dizziness is present, the head temperature decrease takes longer to recover, and the transient tail spike diminishes or disappears. (B, C, D) Viral infection diminishes tail vasodilations and impairs a mouse’s natural response to the provocative motion. At time t = 0, mice experience a 20-minute provocative motion and exhibit a significant increase in tail temperature. Δ tails are computed and are corrected for ambient temperature. Findings suggest that olcegepant did not protect against virus-induced changes in tail vasodilation at 3 dpi in all the strains tested. (E, F, G) Viral infection impacts recovery from hypothermia after provocative motion. (H) Second-order curve fits the observed recovery of head temperatures after provocative motion to baseline. Across all strains, infected mice experienced delayed temperature recovery compared to the pretest, with longer recovery profiles (**** =P < 0.0001). (I) No protective effects of olcegepant were seen in temperature recovery for any of the tested strains.